Research
Originally the Vienna Science Chair of Bioinformatics, the research group was founded 2005 on winning a five-year WWTF startup grant together with its partners. It then became a permanent chair embedded in the Dept of Biotechnology and was endowed by Boku University Vienna until 2013. It now forms an independent Research Group at the newly founded Institute for Molecular Biotechnology.
Besides funds for the foundation of the group, the startup
grant supports group internal research into non-genetic
sources of individuality in the model organism Drosophila
melanogaster (fruit fly). It is well known that identical
twins, which share the exact same genes, still exhibit
differences in their looks, behavioural character, and other nature,
even if they grow up in the same environment. The mechanisms
that may be responsible for this are only beginning to be
understood.
Recently it was shown that unicellular organisms respond to
random fluctuations over time. For both prokaryotes and
eukaryotes, this can be understood by noise affecting the gene
expression machinery at the transcription level. Two reporter
genes with the same promoter driving proteins with green or
red fluorophores may randomly either receive the components of the
transcription machinery, or not.
In more complex multi-cellular organisms, other mechanisms like epigenetic effects might play a larger role. Still, it has been observed that genetically identical mice in drug trials can respond differently to a drug candidate. We are interested in the effects of random fluctuations in multi-cellular organisms.