News from the group:
Research Exchange Fellowships - IAESTE (apply)
CAMDA 2023 - ISMB Conference Track, 26-27 July, Lyon, France (read more)
World-leading patient stratification - graph based cancer data integration (read more)
Confirming molecular mechanisms of tendon regeneration - a powerful ovine fetal model (read more)
CAMDA 2022
ISMB Conference Track,
11-12 July, Madison, USA
(read more)
NVIDIA GTC Best Poster Award
for MM Kańduła
at GTC'18
Outstanding Presentation Prize
for MM Kańduła
at CAMDA'17
Outstanding Presentation Prize
for PP Łabaj
at CAMDA'15 (photo)
Austrian Marshall Plan Foundation scholarship
for MM Kańduła
at Boston University
OeAW APART fellowship
for PP Łabaj

Sequencing Quality Control (SEQC) project,
MAQC Consortium 2011–2014 (read more)
Host–parasite interactions in biocontrol, WWTF grant 2010–2013 (read more)

Power and limitations of RNA-Seq,
FDA SEQC, Nature Biotechnology (read more)
Characterization and improvement of RNA-Seq precision,
Bioinformatics (read more)
Impact of heavy tails in microarray analysis, Bioinformatics (read more)
Novel conserved repeats in sorting signals,
FEBS Journal (read more)
Sound sensation gene,
Nature communications
(read more)
RNA interference in ageing research,
Gerontology (read more)

Host–parasite interactions in biocontrol

The majority of plant diseases are caused by fungi and, in spite of chemical fungicides in pest management, these fungi still are responsible for extensive economical losses. Chemical fungicides can have drastic effects on the environment and the consumer, and a reduction of their Trichoderma atroviride growing along the hyphae of a host fungus. [Photo by Verena Seidl, TU Vienna, and Nick Read, Univ. of Edinburgh] application in agriculture is therefore desirable. Trichoderma atroviride is a filamentous cosmopolitan fungus, commonly found in soil, and isolated from both tropic as well as temperate climates. It is best known for its biocontrol capabilities against a range of phytopathogenic fungi including Rhizoctonia solani and Botrytis cinerea, which are pests of hundreds of plant crops, including tomatoes, beans, cucumber, strawberries, cotton and grapes.

Although more than 50 different Trichoderma-based agricultural products are registered, the knowledge of the underlying intracellular mechanisms and the involved genes which enable the fungus to antagonize phytopathogenic fungi is still very limited. During the mycoparasitic interaction, the host fungus is recognized and attacked, followed by nutrient utilisation by the mycoparasite, killing the host before or just after invasion. Investigations on the underlying signal transduction pathways revealed that G-protein signalling and pathways involving MAP-kinases play important roles in the recognition of host-derived signals and in the activation of the mycoparasitic response in T. atroviride

The aim of the project is to identify mycoparasitism-relevant agents specifically induced by a living host fungus by combining genome-wide expression profiling and proteomic approaches. By including signaling mutants with altered mycoparasitic features as tools, information about key molecular processes participating in mycoparasitism will be obtained.


We collaborate with Drs Susanne Zeilinger and Martina Marchetti at the Technical University of Vienna. Dr Zeilinger is the expert on Trichoderma and leads the project. Dr Marchetti is responsible for the study of protein expression and phosphorylation, while our group contributes microarray design, transcription level expression profiling, and data analysis.


Support for this project was won through competition in the WWTF Life Sciences Call 2009.